What is MCAS?
MCAS stands for mast cell activation syndromeMast cells are immune cells found in many tissues. They play a key role in the immune system and in allergic reactions. In MCAS, mast cells, important cells in our immune system, are overactive. Sometimes, there are also more mast cells present in tissues. These cells release substances that trigger inflammatory reactions, which can lead to a wide range of symptoms. These symptoms often resemble allergic reactions and can affect various organ systems.
Why is this important?
MCAS is common in adults and children with persistent symptoms after an infectious disease (PAIS), such as COVID-19, Q fever, Lyme disease, or ME/CFS. The risk of developing MCAS is also increased in certain connective tissue diseases and in cases of persistent symptoms after COVID-19 vaccination. However, it is still often missed. Early recognition helps to better understand symptoms and initiate appropriate treatment.
What's in the fact sheet?
- Explanation of what MCAS is and how it develops
- Characteristics and symptoms associated with MCAS
- How to Recognize and Diagnose MCAS
- Possible triggers and causes
- Advice and treatment options, such as avoiding triggers and medications (e.g., antihistamines or mast cell stabilizers)
Who is this information for?
This fact sheet is intended for both healthcare professionals and patients. Healthcare providers will receive practical guidance on recognition and treatment, while patients will find tips for better managing symptoms and triggers. The fact sheet (double-sided A4) can be viewed digitally below. Patients may also find it helpful to print it and take it with them to a healthcare provider, school, or other people around you to inform them about MCAS and your potential limitations as a patient.
Do you have any questions? Discuss them with your doctor or GP. Healthcare providers can contact C-Support if they have any questions.
