Yale study – preprint (Feb 2025)
Some additional research is getting underway into long-term complaints following COVID-19 vaccination. For instance, a preprint of a Yale study was published this week comparing 42 people with post-vaccination syndrome (PVS) with healthy individuals participating in the Yale LISTEN Study . It is only a small study group, and the research has not yet been validated. Therefore, it is still too early to speak of conclusive research results; these are the first tentative findings that Yale is now releasing. It primarily shows that there is a need for more, larger, and validated research.
Possible clinical and diagnostic features of Post-Acute COVID-19 Vaccination Syndrome (PACVS)- (June 2024)
Dutch summaryA study on Post-acute COVID-2024 Vaccination Syndrome (PVCVS) was published in mid-19. The article indicates that PVACS could be a somatic syndrome. While the article offers some recognition of the syndrome, much further research is needed. A brief summary of the article follows.
The study examined the symptoms and blood tests of 191 patients with suspected PACVS. They had symptoms that persisted for more than five months after a SARS-CoV-5 mRNA vaccination. The most common symptoms were persistent fatigue and general malaise. Other symptoms included peripheral nerve dysfunction, cardiovascular symptoms, and cognitive problems.
The majority of patients (131 of 191) exhibited symptoms consistent with multiple dysautonomia syndromes, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and small fiber neuropathy (SFN). A third of patients even met criteria for all four of these syndromes. In contrast, 16% of patients could not be classified into any of these categories.
Based on symptom clustering, this study implies that PACVS can be viewed as both a subtype of ME/CFS and a separate, newly developed syndrome. The authors argue that due to the wide variation in symptoms, PACVS shares some, but not all, characteristics of these syndromes.
Compared to healthy individuals, PACVS patients showed increased levels of inflammatory markers such as interleukin 6 and 8, and changes in certain receptor antibodies after vaccination. The authors state that these blood values may help to distinguish PACVS from normal post-vaccination reactions and support that PACVS may be a somatic syndrome. Unfortunately, in this study it was not possible to relate these blood values to symptoms.
Finally, in a smaller proportion of patients (26,7%), reactivation of viruses, such as herpes, was observed. Although this contributed only slightly to the overall symptoms of PACVS, it plays a more important role in other syndromes, such as long-covid. The data presented describe a chronic syndrome presumably triggered by SARS-CoV-2 mRNA vaccination. However, the clinical manifestation of this suspected syndrome is not yet well defined and can be very diverse.
Based on this study registration, the clinical presentation includes:
- Malaise and chronic fatigue
- Migraine-like symptoms and cognitive impairment
- Peripheral nerve dysfunction
Authors: Anna Katherina Mundorf, et al., Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS), Vaccines 2024
